Challenges in MRD measurement by multiparameter flow cytometry in AML

The virtual AML Hub Satellite Symposium at the 46^th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT) brought together an international panel of experts to discuss how measurable residual disease (MRD) impacts outcome of stem cell transplantation in AML, now and in the future. Professor Jacqueline Cloos, Amsterdam University Medical Center, Amsterdam, NL, presented the topic ‘Challenges in MRD measurement by multiparameter flow cytometry in AML.’

Following a brief overview of the techniques used to assess MRD in AML, Professor Jacqueline Cloos focuses her presentation on the technical aspects of multiparameter flow cytometry, one of the most commonly used methods for MRD detection. She describes the different approaches for multiparameter flow cytometry MRD assessment and the limitations of this technique. She also reports on the European LeukemiaNet (ELN) Working Party recommendations for MRD measurement by multiparameter flow cytometry in AML.